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Related Concept Videos

Bone Disorders01:29

Bone Disorders

3.8K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
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Bone Remodeling01:40

Bone Remodeling

38.5K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
38.5K
The Bone Matrix01:18

The Bone Matrix

4.2K
Bone contains a relatively small number of cells entrenched in a matrix of collagen fibers that provide an adherent surface for inorganic salt crystals. Both components of the matrix, organic and inorganic, contribute to the unusual properties of bone. Without collagen, bones would be brittle and shatter easily. Without mineral crystals, bones would flex and provide little support. This can be observed by an experiment: when the minerals of a bone are dissolved by soaking the bone in...
4.2K
Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

3.1K
Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
3.1K
Gross Anatomy of Bone01:17

Gross Anatomy of Bone

6.0K
The two main features of a long bone are the diaphysis and the epiphysis.
The diaphysis is the tubular shaft that runs between the proximal and distal ends of the bone. The walls of the diaphysis are composed of dense and hard compact bone made of numerous osteons — the functional unit of the compact bone. The hollow region in the diaphysis is called the medullary cavity, which harbors the bone marrow. In infants and children, this marrow cavity is filled with red marrow, whereas in...
6.0K
Spongy Bone01:09

Spongy Bone

4.9K
All bones comprise an outer layer of compact bone, and an interior made up of spongy bone tissue, also called cancellous or trabecular bone. In long bones, spongy bone tissue is mainly found in the interior of the epiphyses (broad ends of the bone).
Spongy bone is more porous, and less dense compared to compact bone. It is composed of concentric lamellae that are arranged irregularly to form the trabecular network. In some bones, the spaces between trabeculae contain red marrow, where...
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Updated: Aug 27, 2025

Murine Hind Limb Long Bone Dissection and Bone Marrow Isolation
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Murine Hind Limb Long Bone Dissection and Bone Marrow Isolation

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Adynamic bone disease: Revisited.

Sonia Sharma1, Ankur Gupta2

  • 1Pediatric Nephrology, Max Superspeciality Hospital, Shalimar Bagh, New Delhi, India.

Nefrologia
|September 26, 2022
PubMed
Summary
This summary is machine-generated.

Adynamic bone disease (ABD) is a growing concern in chronic kidney disease-mineral bone disorder (CKD-MBD) management. This review covers updated insights into ABD

Keywords:
Adynamic bone diseaseBiopsia óseaBone biopsyCKD-MBDERC-TMOEnfermedad ósea adinámica

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Area of Science:

  • Nephrology
  • Endocrinology
  • Bone Metabolism

Background:

  • Bone and mineral disorders are critical in chronic kidney disease (CKD) patient care.
  • Chronic kidney disease-mineral bone disorder (CKD-MBD) encompasses various bone pathologies.
  • Adynamic bone disease (ABD) is an increasingly prevalent condition within CKD-MBD.

Purpose of the Study:

  • To review the updated pathophysiology of adynamic bone disease (ABD).
  • To identify current risk factors associated with ABD development in CKD patients.
  • To discuss contemporary management strategies for ABD.

Main Methods:

  • Literature review of recent studies on CKD-MBD and ABD.
  • Analysis of pathophysiological mechanisms contributing to ABD.
  • Synthesis of clinical data on risk factors and treatment outcomes.

Main Results:

  • The pathophysiology of ABD involves suppressed bone turnover.
  • Key risk factors include older age, diabetes mellitus, and excessive calcium or vitamin D supplementation.
  • Management focuses on addressing underlying causes and optimizing bone health.

Conclusions:

  • Adynamic bone disease (ABD) requires careful monitoring and tailored management in CKD patients.
  • Understanding updated pathophysiology and risk factors is crucial for effective intervention.
  • Further research is needed to refine treatment protocols for ABD.