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Drug-Induced Self-Assembly Cascade Nanoreactor for Synergistic Tumor Therapy
Weicai Wang1,2, Yuanyuan Wang1, Minghui Ma1
1Collaborative Innovation Centre of Tumour Marker Detection Technology, Equipment and Diagnosis-Therapy Integration in Universities of Shandong, Shandong Province Key Laboratory of Detection Technology for Tumour Makers, School of Chemistry and Chemical Engineering, Linyi University, Linyi 276005, China.
This study introduces a novel biocompatible nanoreactor for cancer therapy. The nanoreactor combines starvation and photodynamic therapy (PDT) for enhanced tumor suppression and improved clinical potential.
Area of Science:
- Biomedical Engineering
- Nanotechnology
- Cancer Therapy
Background:
- Developing biocompatible and biodegradable drug delivery systems is crucial for effective cancer treatment.
- Current cancer therapies often face challenges with specificity and efficacy.
Purpose of the Study:
- To construct a cancer-targeted cascade bioreactor for synergistic starvation and photodynamic therapy (PDT).
- To enhance tumor suppression by combining glucose deprivation and oxygen generation for improved photodynamic efficacy.
Main Methods:
- Human serum albumin (HSA) was engineered to encapsulate glucose oxidase (GOx), catalase (CAT), and chlorin e6 (Ce6).
- AS1411 aptamer was incorporated for active tumor targeting, leveraging the enhanced permeability and retention (EPR) effect.
- The nanoreactor's performance was evaluated through in vitro and in vivo studies.
Main Results:
- The engineered HSA nanoreactor demonstrated effective targeting of nucleolin-overexpressed tumors.
- The cascade reaction within cancer cells produced oxygen, enhancing singlet oxygen generation for PDT.
- Synergistic starvation and enhanced PDT significantly improved therapeutic efficacy in preclinical models.
Conclusions:
- The developed protein nano-cascade reactor offers a promising strategy for synergistic cancer therapy.
- This approach shows potential for clinical translation in cancer treatment due to its biocompatibility and biodegradability.
