Interaural delay modulates the prepulse inhibition of the startle reflex induced by binaural gap in humans

This study used prepulse inhibition (PPI) of the acoustic startle reflex as a physiological measure to determine the sensitivity to a break in interaural correlation (BIC) in binaural gap detection and compared this physiological measure with the traditional behavioral measure. Results show that BIC could be used as a prepulse to induce PPI at different interaural delays. Furthermore, the PPIs induced by BIC at an interaural delay of 4 ms, but not 0, 2, or 8 ms, were correlated with the BIC delay threshold. These findings suggest that the BIC-induced PPI paradigm may serve as an objective measure of binaural gap detection.