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Biomarkers in Hypertension and Hypertension-related Disorders

Patrícia de Carvalho Ribeiro1, Lucas Felipe Oliveira2,3, Daniel Mendes Filho4

  • 1Department of Oncology, Georgetown University, Washington, DC, United States.

Current Medicinal Chemistry
|September 26, 2022
PubMed

Insights

Systemic arterial hypertension (SAH) is a major risk factor for secondary diseases. Biomarkers offer a promising non-invasive approach for early diagnosis and improved management of SAH and related conditions.

Area of Science:

  • Cardiology
  • Nephrology
  • Neurology

Background:

  • Systemic arterial hypertension (SAH) is a prevalent global health issue and a significant risk factor for cardiovascular and renal diseases.
  • Early and accurate diagnosis of SAH is crucial for preventing severe secondary health outcomes.
  • Biomarkers are increasingly recognized as vital tools in understanding and managing hypertension and its complications.

Approach:

  • This review discusses the application of biomarkers in the diagnosis, prognosis, and management of SAH.
  • It explores the role of biomarkers in various hypertension-related disorders, including stroke, myocardial infarction, and chronic kidney disease.
  • The focus is on leveraging biomarkers for non-invasive assessment and personalized therapeutic strategies.

Key Points:

  • Biomarkers can aid in the early detection and risk stratification of patients with SAH.
  • Specific biomarkers are relevant for predicting and managing conditions like ischemic stroke, intracerebral hemorrhage, and chronic kidney disease.
  • Identifying a comprehensive panel of biomarkers can enhance treatment efficacy and patient outcomes.

Conclusions:

  • Biomarker research provides a pathway for developing non-invasive diagnostic and prognostic tools for SAH.
  • Utilizing biomarkers can lead to improved risk assessment and tailored therapy management for hypertension.
  • The ultimate goal is to enhance patient quality of life and prevent adverse events associated with SAH.

Keywords:
Systemic arterial hypertensionbiomarkerscardiovascular diseasegenomicshypertensionmetabolomicsproteomicstranscriptomics

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