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Updated: Aug 27, 2025

Surgical Swine Model of Chronic Cardiac Ischemia Treated by Off-Pump Coronary Artery Bypass Graft Surgery
Published on: March 27, 2018
[Coronary Artery Bypass Grafting for Acute Coronary Syndrome]
1Department of Cardiovascular Surgery, Gifu University, Gifu, Japan.
Insights
Coronary artery bypass grafting (CABG) offers better long-term survival than percutaneous coronary intervention (PCI) for acute coronary syndrome (ACS) patients, especially those with multi-vessel disease. CABG should be considered despite current guidelines favoring PCI.
Area of Science:
- Cardiology
- Cardiac Surgery
Background:
- Current guidelines recommend percutaneous coronary intervention (PCI) over coronary artery bypass grafting (CABG) for acute coronary syndrome (ACS).
- CABG is underutilized in ACS despite its higher success in complete revascularization, particularly for multi-vessel disease.
Purpose of the Study:
- To compare the efficacy and long-term outcomes of CABG versus PCI in patients with acute coronary syndrome.
Main Methods:
- Comparative analysis of revascularization strategies (PCI vs. CABG) in ACS patients.
- Evaluation of operative mortality and long-term survival rates.
Main Results:
- Operative mortality for CABG was found to be comparable to primary PCI.
- Coronary artery bypass grafting demonstrated significantly better long-term survival rates compared to PCI.
Conclusions:
- Coronary artery bypass grafting (CABG) should be considered as a viable one-stage complete revascularization option for acute coronary syndrome (ACS) patients.
- The potential benefits of CABG, including superior long-term survival, warrant discussion within heart teams, even for hemodynamically unstable patients.
Abstract:
According to the current guidelines, patients who presented with acute coronary syndrome (ACS) are preferably treated with percutaneous coronary intervention( PCI) than with coronary artery bypass grafting (CABG). However, despite a higher success rate of complete revascularization especially for patients with multiple vessel disease, CABG seems to be underused after ACS. Recent studies comparing different revascularization strategies( PCI vs CABG) for ACS demonstrated that operative mortality after CABG was comparable to that after primary PCI. Furthermore, long-term survival rate of CABG was significantly better than that of PCI. Therefore, even when a hemodynamically unstable patient with ACS was admitted to hospital, the option of one-stage complete revascularization by CABG should be discussed by heart team.
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