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Published on: September 12, 2014
Sutureless Lyophilized Amniotic Membrane Grafting for Corneal Epithelial Defects
Maxime Delbarre1, William Boucenna, Françoise Froussart-Maille
1Ophthalmology Department (M.D., F.F.-M.), Percy Military Hospital, Clamart, France; and Ophthalmology Department (W.B.), Amiens University Hospital Center, Amiens, France.
Objectives:
To report the tolerability, safety, and efficacy of the lyophilized amniotic membrane (AM) Visio-AMTRIX placed under a bandage contact lens (BCL) in treating persistent epithelial defects (PEDs).
Methods:
This retrospective study included consecutive patients with PEDs treated with a lyophilized AM placed under the BCL. Patients with PEDs who did not respond to medical treatment were included. Patients with a follow-up time less than 3 months were excluded.
Results:
Eleven eyes of 11 patients (mean age, 61.6±15.9 years) were included. Time from PED presentation to AM transplantation (AMT) was 27.7±4.9 days, with the mean PED area of 13.2±11.3 mm2. Complete resolution was achieved in 8 of 11 eyes after a single AM graft. The epithelial defect persisted after the first AMT in three eyes (27.3%), and a second graft was necessary to achieve complete healing. The corneal epithelial defect healed in an average of 11.0±4.4 days after grafting. After PED resolution, the best-corrected visual acuity significantly improved from 0.66±0.30 logMAR (20/91 Snellen) to 0.58±0.24 logMAR (20/77 Snellen) (P=0.036) compared with baseline. The AM resorbed within 2 weeks in all cases. No complication or recurrence was observed.
Conclusions:
A sutureless lyophilized AM under the BCL can resolve PEDs with a significant improvement in vision.
