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Published on: October 30, 2013
[The Analysis of Tumor Immune Microenvironment in Muscle-Invasive Bladder Cancer Treated with Neoadjuvant
Daiki Ikarashi1, Shigehisa Kitano, Tetsuya Nakatsura
1Dept. of Urology, Iwate Medical University School of Medicine.
Abstract:
The relationship between the tumor microenvironment and the clinical efficacy of neoadjuvant chemotherapy is unclear in patients with cT2-4aN0M0 muscle-invasive bladder cancer. We examined the tumor microenvironment in these patients via multiplex fluorescence immunohistochemistry. This comprehensive analysis of the immune microenvironment of a muscle- invasive bladder cancer specimen revealed that preexisting tumor-infiltrating proliferating CD8+ T cells and CD204+ cells are indicators of the response to neoadjuvant chemotherapy and that CD204+ cells can be considered an unfavorable prognostic factor in these patients.
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