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Top-down modulation and cortical-AMG/HPC interaction in familiar face processing.

Xiaoxu Fan1, Qiang Guo2, Xinxin Zhang3

  • 1Department of Psychology, University of Washington, Seattle, WA, 98105, United States.

Cerebral Cortex (New York, N.Y. : 1991)
|September 26, 2022
PubMed
Summary
This summary is machine-generated.

Recognizing familiar faces involves later neural responses in the ventral temporal cortex (VTC) and medial parietal cortex (MPC). This suggests familiarity enhances face perception through top-down modulation and interactions with the amygdala/hippocampus (AMG/HPC).

Keywords:
face perceptionfamiliaritysEEGtop-down

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Area of Science:

  • Neuroscience
  • Cognitive Neuroscience
  • Neuroimaging

Background:

  • Human face recognition is rapid but the neural mechanisms are not fully understood.
  • Familiarity plays a crucial role in recognizing known individuals.

Purpose of the Study:

  • To investigate the neural basis of familiar face perception.
  • To identify brain regions and mechanisms involved in distinguishing familiar from unfamiliar faces.

Main Methods:

  • Recorded intracranial electrophysiological signals from epilepsy patients.
  • Monitored brain activity in the ventral temporal cortex (VTC), superior/middle temporal cortex (STC/MTC), medial parietal cortex (MPC), and amygdala/hippocampus (AMG/HPC).
  • Presented participants with famous faces, stranger faces, and common objects.

Main Results:

  • Familiarity-sensitive neural responses in posterior VTC and MPC occurred later than initial face-selective responses.
  • Viewing famous faces increased neural coupling between cortical areas and the AMG/HPC across multiple frequency bands.
  • Identified top-down modulation of face representations and interactions between cortical areas and AMG/HPC.

Conclusions:

  • Familiarity enhances face representations after initial extraction.
  • Neural interactions between cortical face areas and the AMG/HPC are critical for familiar face perception.
  • Findings elucidate the neural underpinnings of recognizing familiar individuals.