New Jatrophane-Type Diterpenoids from Euphorbia kansui as Potential MDR Reversal Agents
Qiong Zheng1, Ning-Yu Chen1, Si-Qing Lou1
1College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, 310014, P. R. China.
Abstract:
A serial jatrophane-type diterpenoids, comprised with three undescribed compounds kanesulones C-E (1-3) and four known ones (4-7), were obtained from the roots of Euphorbia kansui. The structures of compounds 1-3 were elucidated by detailed interpretation of their spectroscopic data, especially 2D-NMR and HR-ESI-MS, the absolute configuration of 1 was revealed by single crystal X-ray diffraction. These isolates were assayed for their multidrug resistance reversing activities on human breast adenocarcinoma cell line MCF-7/ADR. Compound 1 possessed potential as low toxic MDR modulator that could promote the efficacy of anticancer drug adriamycin ca. 85-fold at 5 μM, as 12 times stronger than the positive drug verapamil.
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