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DNA damage response signaling: A common link between cancer and cardiovascular diseases

Sepideh Nikfarjam1,2, Krishna K Singh1,2

  • 1Department of Anatomy and Cell Biology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON, Canada.

Cancer Medicine
|September 26, 2022
PubMed

Insights

DNA damage response (DDR) pathways are crucial for maintaining genome stability. Dysregulation of DDR is linked to both cancer and cardiovascular diseases (CVDs), highlighting their interconnectedness.

Area of Science:

  • Genomic instability and its role in human diseases.
  • Molecular mechanisms of DNA damage response (DDR).

Background:

  • DNA damage response (DDR) signaling maintains genomic and proteomic homeostasis.
  • Dysregulation of DDR pathways is associated with cancer and cardiovascular diseases (CVDs).
  • Impaired DDR is a hallmark of cancer and implicated in CVD pathophysiology.

Purpose of the Study:

  • To review different DDR pathways and their cross-talk.
  • To explore the role of DDR in cancer and CVDs.
  • To discuss interventional strategies for genomic instability in CVDs.

Main Methods:

  • Comprehensive literature review of DDR pathways.
  • Analysis of functional cross-talk among DDR mechanisms.
  • Examination of DDR's role in cancer and CVD pathophysiology.

Main Results:

  • DDR pathways are essential for maintaining genome health.
  • Altered DDR signaling is implicated in cancer and CVDs.
  • There is a complex interplay between DDR, cancer, and CVDs.

Conclusions:

  • DDR plays a critical role in both cancer and CVDs.
  • Understanding DDR mechanisms offers potential therapeutic targets for CVDs.
  • Further research is needed to explore interventional strategies for genomic instability in CVDs.
Keywords:
DNA damage repaircancercardiovascular diseaseoxidative stress

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