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Updated: Aug 27, 2025
09:59
Coherent anti-Stokes Raman Scattering CARS Microscopy Visualizes Pharmaceutical Tablets During Dissolution
Published on: July 4, 2014
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Monitoring and Analysis Solid Formulation Dissolution Phenomenon with Image Recognition Technologies.
Haoyu Wang1, Chiew Foong Kwong1,2, Qianyu Liu3
1Department of Electrical and Electronic Engineering, University of Nottingham Ningbo China, Ningbo, China.
Computational Intelligence and Neuroscience
|September 26, 2022
Summary
A new image recognition system automates tablet volume analysis during dissolution testing, improving operability and accuracy for drug formulation development and bioequivalence studies.
Area of Science:
- Pharmaceutical Sciences
- Biomedical Engineering
- Analytical Chemistry
Background:
- Dissolution testing is critical for solid dosage form quality and drug bioequivalence.
- Traditional methods are often manual, tedious, and lack precise operability.
- Previous video analysis relied on fixed tablets and manual post-processing.
Purpose of the Study:
- To develop an automated image recognition system for real-time tablet volume analysis during dissolution.
- To overcome the limitations of manual and semi-automated dissolution testing procedures.
- To enhance the efficiency and accuracy of solid formulation quality control.
Main Methods:
- Implemented a novel image recognition system with visible and infrared cameras on a dissolution tester.
- Utilized image processing for binary analysis of collected tablet images.
- Developed algorithms to automatically track tablet movement and calculate pixel area for volume change.
Main Results:
- The system successfully automates tablet tracking and volume change analysis.
- It accurately records volume changes regardless of tablet disintegration or corrosion.
- This offers a more operable and efficient alternative to traditional methods.
Conclusions:
- The developed image recognition system significantly improves dissolution testing operability.
- It provides accurate, automated monitoring of tablet volume changes.
- This technology enhances quality control in pharmaceutical research and development.
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