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Updated: Aug 27, 2025

Analysis of Human T Cell Activity in an Allogeneic Co-Culture Setting of Pre-Treated Tumor Cells
Published on: March 7, 2025
Time isn't kind to female T-cells
Cassandra J McGill1,2, Bérénice A Benayoun3,4,5,6,7
1Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA.
Abstract:
While investigating sex-differences in T-cell aging, Mkhikian et al., identified a role for excessive IL-7 signaling and N-glycan branching in age-related mouse and human female T-cell dysfunction. These findings point to the increasingly-recognized importance of the impact of biological sex on immune aging and delineate new targetable pathways in age-related immune dysfunction.
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