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Assessment of Vascular Function in Patients With Chronic Kidney Disease
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Activated Platelets, the Booster of Chronic Kidney Disease and Cardiovascular Complications

Shuiqin Gong1, Chenyu Wang1, Jiachuan Xiong1

  • 1Department of Nephrology, The Key Laboratory for the Prevention and Treatment of Chronic Kidney Disease of Chongqing, Chongqing Clinical Research Center of Kidney and Urology Diseases, Xinqiao Hospital, Army Medical University (Third Military Medical University), Chongqing, China.

Kidney Diseases (Basel, Switzerland)
|September 26, 2022
PubMed

Insights

Chronic kidney disease (CKD) and its cardiovascular complications pose significant health challenges. Platelets play a key role in both CKD and related cardiovascular diseases, highlighting a potential therapeutic target.

Area of Science:

  • Nephrology
  • Cardiology
  • Hematology

Background:

  • Chronic kidney disease (CKD) is a growing global health concern.
  • Cardiovascular diseases (CVDs) are the leading cause of mortality in advanced CKD patients.
  • Effective management of CKD-related cardiovascular complications remains a significant clinical challenge.

Purpose of the Study:

  • To investigate the role of platelets in the pathophysiology of CKD.
  • To explore the involvement of platelets in CKD-associated cardiovascular diseases.
  • To identify potential therapeutic strategies targeting platelet function in CKD.

Main Methods:

  • Review of current literature on platelet biology and function.
  • Analysis of studies investigating platelet activation and aggregation in CKD.
  • Examination of research on the link between platelets and cardiovascular complications in CKD patients.

Main Results:

  • Platelets are implicated in various physiological and pathological processes relevant to CKD.
  • Evidence suggests platelets contribute to the development and progression of CKD-related CVDs.
  • Platelet activation and dysfunction are observed in CKD patients.

Conclusions:

  • Platelets are critical players in both CKD and its cardiovascular complications.
  • Targeting platelet pathways may offer novel therapeutic avenues for managing CKD patients.
  • Further research is warranted to fully elucidate platelet mechanisms in CKD-CVD.

Keywords:
Cardiovascular complicationsChronic kidney diseasePlatelets

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