Related Experiment Video
Updated: Aug 27, 2025

A Method for Measuring RNA N6-methyladenosine Modifications in Cells and Tissues
Published on: December 5, 2016
The role of RNA m6A methylation in lipid metabolism
Yuting Wang1, Yujie Wang2, Jiarui Gu1
1Department of Endocrinology, The Second Affiliated Hospital of Soochow University, Suzhou, China.
Abstract:
The m6A methylation is the most numerous modification of mRNA in mammals, coordinated by RNA m6A methyltransferases, RNA m6A demethylases, and RNA m6A binding proteins. They change the RNA m6A methylation level in their specific manner. RNA m6A modification has a significant impact on lipid metabolic regulation. The "writer" METTL3/METTL14 and the "eraser" FTO can promote the accumulation of lipids in various cells by affecting the decomposition and synthesis of lipids. The "reader" YTHDF recognizes m6A methylation sites of RNA and regulates the target genes' translation. Due to this function that regulates lipid metabolism, RNA m6A methylation plays a pivotal role in metabolic diseases and makes it a great potential target for therapy.
Related Concept Videos
RNA Stability
RNA Editing
MicroRNAs
mRNA Stability and Gene Expression
Cis-acting Elements involved in mRNA stability
Types of RNA
RNA Performs Diverse...
Regulation of Expression at Multiple Steps

