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Deregulated miRNA clusters in ovarian cancer: Imperative implications in personalized medicine

Amoolya Kandettu1, Divya Adiga1, Vasudha Devi2

  • 1Department of Cell and Molecular Biology, Manipal School of Life Sciences, Manipal Academy of Higher Education, Manipal, Karnataka 576104, India.

Genes & Diseases
|September 26, 2022
PubMed

Insights

miRNA clusters (MCs) drive ovarian cancer (OC) progression by promoting cancer hallmarks. Aberrant MCs are key in OC pathogenesis and offer potential for clinical management.

Area of Science:

  • Gynecological Oncology
  • Molecular Biology
  • Cancer Genetics

Background:

  • Ovarian cancer (OC) is a leading cause of cancer death, often diagnosed late.
  • MicroRNAs (miRNAs) are small non-coding RNAs crucial in gene regulation.
  • miRNA clusters (MCs) are transcribed as single units and play roles in various cancers.

Purpose of the Study:

  • To review the regulation and biological functions of miRNA clusters in ovarian cancer.
  • To highlight the clinical utility of dysregulated miRNA clusters in OC management.

Main Methods:

  • Literature review focusing on miRNA clusters in ovarian cancer.
  • Analysis of regulatory mechanisms and functional roles of MCs.
  • Evaluation of clinical implications of MCs in OC.

Main Results:

  • Abnormal expression of MCs is a key driver in OC pathogenesis.
  • MCs can act as tumor suppressors or oncogenes in OC.
  • Dysregulated MCs contribute to cancer cell hallmarks and disease progression.

Conclusions:

  • MCs are significantly involved in the development and progression of ovarian cancer.
  • Abnormally expressed MCs represent promising biomarkers and therapeutic targets for OC.
Keywords:
DiagnosisDrug resistanceOvarian cancerPrognosisRegulationmiRNA clusters

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