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Related Experiment Videos

Do plasma norepinephrine levels reflect behavioral stress?

J E Dimsdale, D Young, R Moore

    Psychosomatic Medicine
    |July 1, 1987
    PubMed
    Summary

    Plasma norepinephrine levels increase significantly during stress, correlating with blood pressure changes. This suggests peripheral norepinephrine reflects sympathetic nervous system activity impacting the cardiovascular system.

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    Area of Science:

    • Physiology
    • Neuroscience
    • Cardiovascular Research

    Background:

    • Plasma norepinephrine (NE) interpretation is complex due to factors like metabolism and blood flow.
    • Previous research questioned the link between peripheral NE and sympathetic cardiovascular activity.

    Purpose of the Study:

    • To investigate the relationship between peripheral plasma NE levels and cardiovascular responses during psychological stress.

    Main Methods:

    • Eleven healthy men underwent continuous blood withdrawal for plasma NE measurement.
    • Simultaneous blood pressure monitoring (systolic and diastolic) was performed.
    • Subjects were exposed to a psychiatric stress interview and rest conditions.

    Main Results:

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  • Psychiatric stress significantly increased plasma NE levels by 83% (p < 0.001).
  • Systolic and diastolic blood pressures rose by 16 mm Hg and 13 mm Hg, respectively (p < 0.0003 and p < 0.0001).
  • Elevated NE levels showed a significant correlation with increased systolic and diastolic pressures.

    • Conclusions:

    • Increased peripheral plasma NE during stress reflects sympathetic nervous system activation.
    • Peripheral NE levels serve as a relevant indicator of cardiovascular system engagement during stress.