Gene editing monkeys: Retrospect and outlook

Area of Science:

• Biomedical Research
• Genetics and Genomics
• Primate Models

Background:

• Nonhuman primates (NHPs) are valuable models in life science research due to their physiological and genetic similarities to humans.
• NHPs are crucial for studying human disease pathogenesis and for drug screening and development.
• Gene editing technology has become a powerful tool for creating advanced animal models.

Purpose of the Study:

• To review the current advancements in establishing gene-edited nonhuman primate models.
• To focus on the application of gene editing in rhesus and cynomolgus monkeys.
• To discuss limitations, solutions, and future prospects of gene-edited NHP models.

Main Methods:

• Review of current literature on gene editing applications in NHPs.
• Focus on gene editing techniques used in rhesus and cynomolgus monkeys.
• Analysis of challenges and potential improvements in genetically modified NHP model development.

Main Results:

• Gene editing has been successfully applied to create genetically modified NHPs, particularly rhesus and cynomolgus monkeys.
• Significant progress has been made in establishing NHP models for disease research and drug development.
• Various challenges exist in the application and optimization of these models.

Conclusions:

• Gene-edited NHP models offer significant potential for advancing human disease research and therapeutic development.
• Overcoming current limitations is crucial for maximizing the utility of these advanced models.
• The future prospects for gene-edited NHPs are promising, despite existing challenges.