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Related Experiment Video

Updated: Aug 27, 2025

Implementation of a Permeable Membrane Insert-based Infection System to Study the Effects of Secreted Bacterial Toxins on Mammalian Host Cells

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Toxic Shock Syndrome From Group C Streptococcus.

Jocelyn McCullough¹, Shehnaz Wasim¹, Kuschner Zachary²

¹Medical Education, Zucker School of Medicine, Port Jefferson, USA.

|September 26, 2022

Summary

This summary is machine-generated.

Group C Streptococcus bacteremia can cause severe toxic shock syndrome. Early antibiotics and intravenous immunoglobulin (IVIG) may improve survival in patients with this rare but serious infection.

Keywords:

bullous cellulitis critical care gram positive bacteremia group c streptococcus intravenous immunoglobulins (ivig)toxic-shock syndrome

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Last Updated: Aug 27, 2025

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A Murine Model of Group B Streptococcus Vaginal Colonization

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Published on: November 16, 2016

Area of Science:

Infectious Diseases
Critical Care Medicine
Microbiology

Background:

Lower extremity cellulitis is a common presentation requiring prompt treatment.
Toxic shock syndrome (TSS) is a severe, life-threatening multisystem illness.
Group C Streptococcus is a less common cause of invasive infections compared to other streptococcal species.

Observation:

A patient presented with lower extremity cellulitis and subsequently developed Group C Streptococcus bacteremia.
The patient exhibited signs and symptoms consistent with toxic shock syndrome.
Despite broad-spectrum antibiotics (piperacillin/tazobactam, vancomycin, clindamycin) and subsequent meropenem, the patient's condition worsened.

Findings:

Group C Streptococcus was identified as the causative agent of bacteremia and toxic shock syndrome.
Treatment included a 14-day course of meropenem and a three-day regimen of intravenous immunoglobulin (IVIG).
The patient survived for 46 days post-admission but ultimately did not recover.

Implications:

This case highlights the potential for Group C Streptococcus to cause severe invasive disease, including TSS.
Timely administration of appropriate antibiotics and adjunctive therapy with IVIG may be crucial for improving outcomes.
Increased awareness and prompt management are essential to reduce mortality associated with Group C Streptococcus-induced TSS.