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A Case of Fibrillary Glomerulonephritis

Maamannan Venkataraj1, Phani P Morisetti2

  • 1Internal Medicine, Louisiana State University Health Sciences Center, Shreveport, USA.

Cureus
|September 26, 2022
PubMed

Insights

Fibrillary glomerulonephritis (FGN), a rare kidney disease, was diagnosed in a patient with cirrhosis. Further investigation revealed an association with smoldering multiple myeloma.

Area of Science:

  • Nephrology
  • Hematology
  • Oncology

Background:

  • Fibrillary glomerulonephritis (FGN) is a rare kidney disease characterized by microfibrillar deposits in glomeruli.
  • It is often associated with other systemic conditions, necessitating comprehensive diagnostic workups.

Observation:

  • A 63-year-old male with a history of cirrhosis presented with suspected hepatorenal syndrome.
  • Kidney biopsy confirmed Fibrillary glomerulonephritis (FGN).

Findings:

  • The patient's elevated serum kappa-lambda ratio prompted investigation for multiple myeloma.
  • Bone biopsy confirmed smoldering multiple myeloma, a condition strongly associated with FGN.

Implications:

  • This case highlights the importance of considering hematologic malignancies in patients diagnosed with FGN.
  • Early diagnosis of associated conditions like smoldering myeloma is crucial for appropriate patient management.
Keywords:
fibrillaryfibrillary glomerulonephritisgloerulopnephritismyelomanephrology

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