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A Rare Presentation of Penile Calciphylaxis Requiring Partial Penectomy
Abdalhai Alshoubi1, Asma Matougelwerfelli2
1Clinical Anesthesiology and Critical Care Medicine, St. Joseph's Medical Center, Stockton, USA.
Cureus
|September 26, 2022
Summary
Calciphylaxis, a rare condition causing skin necrosis, can occur in patients without kidney disease. This case highlights the severe risks, including sepsis and death, associated with non-uremic calciphylaxis.
Area of Science:
- Nephrology
- Dermatology
- Pathology
Background:
- Calciphylaxis is a rare, severe condition involving microvascular calcification and occlusion.
- It leads to skin necrosis and ulceration, with high morbidity and mortality.
- It is classified as uremic (in end-stage renal disease patients) or non-uremic.
Observation:
- Non-uremic calciphylaxis is exceptionally rare and associated with a high mortality rate due to sepsis.
- Common risk factors include diabetes mellitus, hyperparathyroidism, malignancy, warfarin use, alcoholic liver disease, and autoimmune disorders.
- This report details a case of penile calciphylaxis in a 36-year-old male with type II diabetes and chronic kidney disease.
Findings:
- The patient presented with rapidly progressing penile ulceration and necrosis.
- Skin necrosis characteristic of penile calciphylaxis was observed.
- The patient ultimately died from multiorgan failure secondary to septic shock.
Implications:
- This case underscores the critical mortality risk of non-uremic calciphylaxis, particularly when complicated by sepsis.
- Effective management strategies for calciphylaxis, including wound care, pain management, and sepsis control, are crucial.
- Further research into the pathogenesis and treatment of non-uremic calciphylaxis is warranted given its rarity and severity.
