Related Experiment Video
Updated: Aug 27, 2025
05:41
Therapeutic Evaluation of Fecal Microbiota Transplantation in an Interleukin 10-Deficient Mouse Model
Published on: April 6, 2022
3.0K
Update on gut microbiota in gastrointestinal diseases
Atsushi Nishida1, Kyohei Nishino2, Masashi Ohno2
1Department of Gastroenterology and Hepatology, Nagahama City Hospital, Nagahama 526-8580, Japan. atsuda@belle.shiga-med.ac.jp.
World Journal of Clinical Cases
|September 26, 2022
Summary
The gut microbiota, a vast microbial ecosystem, impacts host health. Dysbiosis, or an altered microbiota, is linked to gastrointestinal diseases, with treatments like fecal microbiota transplantation (FMT) showing promise.
Area of Science:
- Gastroenterology
- Microbiology
- Human Health
Background:
- The human gut hosts trillions of microbes, forming the gut microbiota, which contains significantly more genes than the human genome.
- This microbial community produces vital enzymes and substances, contributing to host health.
- Perturbations in the gut microbiota, termed dysbiosis, are associated with gastrointestinal diseases.
Purpose of the Study:
- To review the association between gut microbiota and gastrointestinal diseases.
- To summarize therapeutic strategies targeting gut microbiota alterations.
Main Methods:
- Literature review focusing on the gut microbiota's role in diseases.
- Analysis of studies on treatments like probiotics and fecal microbiota transplantation (FMT).
Main Results:
- The gut microbiota plays a crucial role in maintaining health.
- Dysbiosis is implicated in conditions such as Clostridioides difficile infection (CDI), inflammatory bowel diseases (IBD), and irritable bowel syndrome.
- Fecal microbiota transplantation (FMT) has demonstrated efficacy in treating recurrent CDI.
Conclusions:
- Targeting the gut microbiota offers potential for preventing and treating gastrointestinal diseases.
- Probiotics and FMT are emerging therapeutic options for various gut disorders.
Related Concept Videos
01:29Bacterial Flora of the Large Intestine
591
The gut microbiome is formed by a vast and diverse community of bacteria that colonizes our large intestine. These bacteria start residing in the gut from birth and continue diversifying throughout life, influenced by factors such as diet, lifestyle, and stress. The gut bacterial community also includes bacteria from food and those that enter the colon through the anus.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
591
01:50What is Monogastric Digestion?
72.1K
The human body contains a monogastric digestive system. In a monogastric digestive system, the stomach only contains one chamber in which it digests food. Several other animal species also have monogastric digestive systems, including pigs, horses, dogs, and birds. This chapter, however, focuses on the human digestive system.
72.1K
01:18Drugs Affecting GI Tract Motility: Antimicrobials as Antidiarrheal Agents
193
Acute diarrhea, a common gastrointestinal disturbance, is characterized by the rapid evacuation of fluid stools, leading to an excessive weight in fluid. This condition typically arises from disorders affecting intestinal water and electrolyte transport. It can be triggered by an increased osmotic load within the intestine, excessive secretion of electrolytes and water, mucosal exudation of protein and fluid, or altered intestinal motility. The primary risks of acute diarrhea are dehydration...
193
01:17Chronic Bowel Disorders: Introduction
526
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
526
01:30Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
397
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
397
01:23Anatomy of the Intestines
73.0K
Although digestion of proteins, carbohydrates, and lipids may begin in the stomach, it is completed in the intestine. The absorption of nutrients, water, and electrolytes from food and drink also occurs in the intestine. The intestines can be divided into two structurally distinct organs—the small and large intestines.
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
73.0K