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Motoric cognitive risk syndrome as a predictor of incident disability: A 7 year follow-up study
Anying Bai1, Weimin Bai2, Hepeng Ju3
1Department of Epidemiology and Biostatistics, School of Public Health, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Background:
Though motoric cognitive risk syndrome (MCR) share risk factors with disability, whether it predict disability remains understudied.
Objectives:
This study aims to examine the association between MCR and incident disability.
Design:
Longitudinal study.
Methods:
MCR was defined as subjective cognitive complaints and objective slow gait speed. Two subtypes of MCR were defined by whether memory impairment (MI) was also present, MCR-MI and MCR-non-MI. Incident activities of daily living (ADL) disability and instrumental activities of daily living (IADL) disability were outcome measures. Multiple logistic regression analysis was used to assess the independent effect of MCR at baseline on the odds of ADL/IADL disability at a 7 year follow-up.
Results:
Among the subjects who were not disabled at baseline and followed for 7 years, 34.66% reported incident ADL disability, and 31.64% reported incident IADL disability. Compared with participants without MCR at baseline, those with MCR had 58% increased odds of incident ADL disability (OR=1.58, 95% CI: 1.19-2.09) and 46% increased odds of incident IADL disability (OR=1.46, 95% CI: 1.13-1.88) after 7 years. MCR-non-MI was associated with a 56.63% increased risk of ADL disability and a 34.73% increased risk of IADL disability. MCR-MI was associated with an even higher risk of IADL disability (OR = 2.14, 95% CI: 1.18-3.88).
Conclusions:
MCR is an independent risk factor for both incident ADL and IADL disability. MCR-MI predicts a higher risk for disability than MCR-non-MI. Early identification of MCR among older adult is recommended and may decrease future risk of disability.
Insights
Motoric cognitive risk syndrome (MCR) is an independent predictor of incident disability. Early identification of MCR in older adults may reduce future disability risk.
Area of Science:
- Gerontology
- Neurology
- Public Health
Background:
- Motoric cognitive risk syndrome (MCR) shares risk factors with disability, but its predictive value for disability is understudied.
- MCR is characterized by subjective cognitive complaints and objective slow gait speed.
Purpose of the Study:
- To examine the association between MCR and incident disability in older adults.
- To determine if MCR subtypes (MCR with memory impairment [MCR-MI] and MCR without memory impairment [MCR-non-MI]) differentially predict disability.
Main Methods:
- A longitudinal study design was employed.
- MCR was assessed at baseline, with incident activities of daily living (ADL) and instrumental activities of daily living (IADL) disability measured at a 7-year follow-up.
- Multiple logistic regression analysis was used to evaluate the independent effect of MCR on disability risk.
Main Results:
- Participants with MCR had significantly increased odds of developing ADL disability (OR=1.58) and IADL disability (OR=1.46) after 7 years.
- MCR-non-MI was associated with a 56.63% increased risk of ADL disability and a 34.73% increased risk of IADL disability.
- MCR-MI demonstrated a higher risk for IADL disability (OR=2.14) compared to MCR-non-MI.
Conclusions:
- MCR is an independent risk factor for both incident ADL and IADL disability.
- MCR with memory impairment poses a greater risk for disability than MCR without memory impairment.
- Early identification and intervention for MCR in older adults are recommended to mitigate future disability.
