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Obesity increases cardiovascular mortality in patients with HFmrEF

Zhican Liu1,2, Yiqun Peng1, Wenjiao Zhao1

  • 1Department of Cardiology, Xiangtan Central Hospital, Xiangtan, China.

Frontiers in Cardiovascular Medicine
|September 26, 2022
PubMed

Insights

High body mass index increases cardiovascular death risk in heart failure with mildly reduced ejection fraction (HFmrEF) patients, particularly women. Obesity is linked to poorer outcomes in this group.

Area of Science:

  • Cardiology
  • Obesity Research
  • Heart Failure Management

Background:

  • High body mass index (BMI) is a known risk factor for heart failure (HF) morbidity and mortality.
  • The prognostic impact of elevated BMI in patients with heart failure with mildly reduced left ventricular ejection fraction (HFmrEF) remains unclear.
  • This study retrospectively investigated the association between BMI and prognosis in HFmrEF patients.

Purpose of the Study:

  • To determine the relationship between body mass index and cardiovascular death risk in HFmrEF patients.
  • To explore potential sex-based differences in this association.
  • To inform risk stratification and management strategies for HFmrEF.

Main Methods:

  • Retrospective analysis of 1,691 HFmrEF patients from Xiangtan Central Hospital.
  • Body mass index assessed as both a continuous and categorical variable.
  • Cox proportional hazards models used to analyze the association with cardiovascular death after adjusting for risk factors.

Main Results:

  • An increase in BMI was significantly associated with an increased risk of cardiovascular death in female HFmrEF patients (7.5% increase per BMI unit).
  • Obese HFmrEF patients had a 1.8-fold increased risk of cardiovascular death compared to normal BMI individuals.
  • The association between BMI and cardiovascular death was less pronounced and not statistically significant in male HFmrEF patients.

Conclusions:

  • Elevated body mass index is linked to a higher risk of cardiovascular death in HFmrEF patients.
  • This association is primarily driven by female patients, with a less significant impact observed in males.
  • Findings highlight the importance of considering BMI, especially in women, for prognosis in HFmrEF.
Abstract

Keywords:
HFmrEFbody mass indexcardiovascularheart failuremortalityobese

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