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Related Experiment Video

Updated: Aug 27, 2025

Bulk and Thin Film Synthesis of Compositionally Variant Entropy-stabilized Oxides

Bulk and Thin Film Synthesis of Compositionally Variant Entropy-stabilized Oxides

Published on: May 29, 2018

Bio-high entropy alloys: Progress, challenges, and opportunities.

Junyi Feng¹, Yujin Tang², Jia Liu²

¹School of Materials Engineering, Shanghai University of Engineering Science, Shanghai, China.

Frontiers in Bioengineering and Biotechnology

|September 26, 2022

Summary

Biological high-entropy alloys (Bio-HEAs) offer improved biocompatibility and mechanical properties for medical implants. This review highlights their potential to overcome limitations of traditional metallic biomaterials for better clinical outcomes.

Keywords:

biocompatibility biological high-entrogy compositon design implant mechanical properties

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Last Updated: Aug 27, 2025

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Area of Science:

Biomaterials Science
Materials Engineering
Biomedical Engineering

Background:

Traditional metallic implants face challenges with biocompatibility and adverse reactions.
There is an urgent need for advanced biomaterials with superior mechanical properties and biocompatibility.
High entropy alloys (HEAs) offer a vast compositional space and excellent mechanical characteristics.

Purpose of the Study:

To review the composition systems of biological high-entropy alloys (Bio-HEAs).
To introduce the biocompatibility and mechanical properties of Bio-HEAs relevant to human bone.
To propose future research directions for Bio-HEAs in biomedical applications.

Main Methods:

Literature review of recent advancements in Bio-HEAs.
Analysis of composition, biocompatibility, and mechanical properties.
Synthesis of findings to identify research gaps and future opportunities.

Main Results:

Bio-HEAs demonstrate promising biocompatibility and tunable mechanical properties.
These properties suggest Bio-HEAs are suitable candidates for biomedical applications, particularly bone implants.
Current research highlights the need for further theoretical and simulation studies.

Conclusions:

Bio-HEAs represent a novel class of biomaterials with significant potential for medical implants.
Further research should focus on composition-performance relationships, degradation, and clinical translation.
Advancing Bio-HEAs could lead to improved long-term clinical success in orthopedic and dental applications.