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Updated: Aug 27, 2025

A Cell Culture Model for Producing High Titer Hepatitis E Virus Stocks
Published on: June 26, 2020
Hepatitis E - epidemiology and clinical course in the largest cohort in the Czech Republic
Matúš Mihalčin1,2, Libuse Husova3, Petra Vasickova4
1Department of Infectious Diseases, Faculty of Medicine, Masaryk University, Brno, Czech Republic.
Introduction:
The majority of hepatitis E (HE) reports come from Western Europe. The aim of the study was to describe the typical epidemiological and clinical characteristics of HE in the Czech Republic.
Methods:
A retrospective analysis of 173 patients with HE.
Results:
At least 90% of cases were autochthonous (HEV-3 genotype). Seventeen patients were treated with ribavirin. Five underwent liver transplants because of fulminant HE. We noted neurological symptomatology in 9 cases. Six patients developed chronic HE.
Conclusions:
There is a possibility of severe health complications caused by the hepatitis E virus in the Czech Republic.
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