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Updated: Aug 27, 2025

Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System
Published on: December 11, 2016
Perspective: repurposed drugs for COVID-19.
Kesara Na-Bangchang1, Supatra Porasuphatana2, Juntra Karbwang1
1Drug Discovery and Development Center, Office of Advanced Science and Technology, Thammasat University, Pathumthani, Thailand.
Proper research design is crucial for evidence-based drug treatment decisions. For COVID-19 therapy, only remdesivir and tocilizumab have FDA approval, while others require more research.
Area of Science:
- Medical Research
- Pharmacology
- Infectious Diseases
Background:
- Physicians require robust scientific and ethical evidence for drug treatment decisions.
- The COVID-19 pandemic necessitated rapid evaluation of potential therapies.
- High-quality research is essential for establishing treatment efficacy and safety.
Purpose of the Study:
- To highlight the importance of rigorous research design in drug treatment.
- To review current evidence for COVID-19 therapies.
- To identify approved and investigational treatments for COVID-19.
Main Methods:
- A literature search was conducted on PubMed.
- Included research articles and guidelines on COVID-19 therapy.
- Focused on therapies for moderate and severe COVID-19 cases.
Main Results:
- Remdesivir and tocilizumab are the only drugs approved by the US FDA for moderate to severe COVID-19.
- These approvals are based on clinical use data.
- Other potential treatments have not yet met approval criteria.
Conclusions:
- Further well-conducted research is necessary for favipiravir, ivermectin, and andrographolide.
- Efficacy and safety of these agents in COVID-19 require confirmation.
- Evidence-based medicine relies on high-quality studies for drug approval and use.
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