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Vaccination completeness in children with rheumatic diseases: A longitudinal, observational multicenter cohort study

Tatjana Welzel1, Jasmin Kuemmerle-Deschner2,3, Constantin Sluka4

  • 1Pediatric Rheumatology, University Children's Hospital Basel, University of Basel, Basel, Switzerland.

Frontiers in Pediatrics
|September 26, 2022
PubMed

Insights

Vaccination completeness is low in Swiss children with pediatric inflammatory rheumatic diseases (PRD), especially for PRD-specific vaccines. Early intervention and collaboration are crucial to improve immunization rates in this vulnerable group.

Area of Science:

  • Pediatric Rheumatology
  • Infectious Diseases
  • Immunology

Background:

  • Children with pediatric inflammatory rheumatic diseases (PRD) face an elevated risk of infections.
  • Vaccinations are critical for preventing vaccine-preventable diseases in this population.

Purpose of the Study:

  • To evaluate vaccination completeness in Swiss PRD patients.
  • To stratify vaccination status based on immunosuppressive treatment (IST).

Main Methods:

  • A multicenter observational cohort study involving PRD patients under 18 years old.
  • Assessment of overall vaccination status, including the Swiss national immunization program (NIP) and PRD-specific vaccines.
  • Stratification of completeness by IST and disease course.

Main Results:

  • Overall vaccination completeness was low at 3.8%.
  • Completeness for NIP vaccinations was 70.1%, while PRD-specific vaccination completeness was only 3.8%.
  • Vaccination rates for pneumococcal, hepatitis B, and HPV were 50.4%, 20%, and 37.9%, respectively.

Conclusions:

  • A significant gap exists in overall and PRD-specific vaccination completeness among children with PRD.
  • Incomplete vaccination status often persists if not addressed early in the disease course.
  • Enhanced collaboration between pediatricians and rheumatologists, standardized assessments, and timely reminders are vital to improve vaccination coverage.
Abstract

Keywords:
immunosuppressioninfection riskvaccinationvaccination adherencevaccination recommendations

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