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Published on: October 8, 2016
Design Strategies of Tumor-Targeted Delivery Systems Based on 2D Nanomaterials
Lin Ding1,2,3,4, Minli Liang2,3,4, Chenchen Li5
1School of Pharmaceutical Sciences and The First Affiliated Hospital, Hainan Medical University, Haikou, 570228, P. R. China.
Abstract:
Conventional chemotherapy and radiotherapy are nonselective and nonspecific for cell killing, causing serious side effects and threatening the lives of patients. It is of great significance to develop more accurate tumor-targeting therapeutic strategies. Nanotechnology is in a leading position to provide new treatment options for cancer, and it has great potential for selective targeted therapy and controlled drug release. 2D nanomaterials (2D NMs) have broad application prospects in the field of tumor-targeted delivery systems due to their special structure-based functions and excellent optical, electrical, and thermal properties. This review emphasizes the design strategies of tumor-targeted delivery systems based on 2D NMs from three aspects: passive targeting, active targeting, and tumor-microenvironment targeting, in order to promote the rational application of 2D NMs in clinical practice.
Insights
Developing advanced 2D nanomaterials (2D NMs) offers targeted cancer therapy, overcoming limitations of conventional treatments. This review explores 2D NMs for precise drug delivery, enhancing treatment efficacy and patient outcomes.
Area of Science:
- Biomedical Engineering
- Materials Science
- Nanotechnology
Background:
- Conventional chemotherapy and radiotherapy lack tumor specificity, leading to severe side effects.
- Targeted cancer therapies are crucial for improving treatment outcomes and patient survival.
- Nanotechnology offers promising solutions for selective cancer treatment and controlled drug release.
Purpose of the Study:
- To review the design strategies for tumor-targeted delivery systems utilizing 2D nanomaterials (2D NMs).
- To highlight the potential of 2D NMs in enhancing cancer therapy through targeted approaches.
- To promote the clinical application of 2D NMs in oncology.
Main Methods:
- Focuses on passive targeting strategies utilizing 2D NMs.
- Explores active targeting approaches with 2D NMs for enhanced tumor cell recognition.
- Discusses tumor-microenvironment targeting strategies enabled by 2D NMs.
Main Results:
- 2D NMs possess unique properties suitable for targeted drug delivery systems.
- Passive, active, and tumor-microenvironment targeting strategies can be effectively implemented using 2D NMs.
- These strategies aim to improve drug accumulation at the tumor site and minimize off-target effects.
Conclusions:
- 2D nanomaterials show significant potential for developing advanced tumor-targeted delivery systems.
- The review provides a framework for designing and applying 2D NMs in clinical cancer therapy.
- Further research and development are needed to translate these nanotechnologies into effective clinical practice.
