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Author Spotlight: Computing the Effects of a Local Radiofrequency Hyperthermia Intervention on Tumor Biomechanics
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Intratumoral Therapy to Make a "Cold" Tumor "Hot": The Jury Is Still Out

Salman R Punekar1, Jeffrey S Weber1

  • 1Laura and Isaac Perlmutter Cancer Center, NYU Grossman School of Medicine, New York, New York.

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
|September 26, 2022
PubMed

Insights

Tilsotolimod, an oligodeoxynucleotide TLR9 agonist, converts cold tumors into hot tumors. This immunotherapy aims to improve responses to immune checkpoint blockade treatments.

Area of Science:

  • Immunology
  • Oncology
  • Pharmacology

Background:

  • Tilsotolimod is an oligodeoxynucleotide TLR9 agonist administered intratumorally.
  • It has been clinically evaluated for its potential in cancer therapy.

Discussion:

  • Tilsotolimod induces changes in the tumor microenvironment.
  • It converts noninflamed, cold tumors into inflamed, hot tumors.

Key Insights:

  • This conversion is hypothesized to enhance tumor immunogenicity.
  • Hot tumors are expected to be more responsive to immune checkpoint blockade.

Outlook:

  • Further clinical evaluation is needed to confirm efficacy.
  • Tilsotolimod represents a potential strategy to overcome resistance to immunotherapy.

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