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The two pairs of parathyroid glands embedded within the posterior surface of the thyroid gland are restricted by a dense capsule around them. These glands comprise two distinct cell populations—parathyroid oxyphil and parathyroid principal cells- pivotal in calcium homeostasis.
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Pharmacodynamics of sustained levels of PTH following palopegteriparatide treatment in adults with hypoparathyroidism.

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Increased Prevalence of Coronary Artery Calcification in Patients with Post-Surgical Hypoparathyroidism.

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Values, preferences, and informational needs of individuals living with ANCA-associated vasculitis: a systematic review.

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Sustained Improvement in Renal Function with Palopegteriparatide in Adults with Chronic Hypoparathyroidism: 2-Year Results from the Phase 3 PaTHway-Trial.

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Management of Hypoparathyroidism.

Aliya A Khan1, Gordon Guyatt2, Dalal S Ali1

  • 1Division of Endocrinology and Metabolism, McMaster University, Hamilton, Canada.

Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research
|September 26, 2022
PubMed
Summary

Hypoparathyroidism (HypoPT) treatment guidelines recommend conventional calcium and vitamin D therapy first. Parathyroid hormone (PTH) replacement is considered when conventional methods are unsatisfactory for managing this rare endocrine disorder.

Keywords:
CELL/TISSUE SIGNALINGDISORDERS OF CALCIUM/PHOSPHATE METABOLISMENDOCRINE PATHWAYSPARATHYROID-RELATED DISORDERS

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Area of Science:

  • Endocrinology
  • Mineral Metabolism
  • Rare Diseases

Background:

  • Hypoparathyroidism (HypoPT) is a rare endocrine disorder causing hypocalcemia with low or normal parathyroid hormone (PTH).
  • Most HypoPT cases (75%) arise post-neck surgery, with 25% from nonsurgical causes.
  • Conventional therapy involves calcium and active vitamin D analogues to normalize mineral levels, but has limitations.

Purpose of the Study:

  • To provide evidence-based recommendations for Hypoparathyroidism (HypoPT) management.
  • To compare the efficacy and safety of conventional therapy versus parathyroid hormone (PTH) replacement.
  • To address special considerations during pregnancy and lactation.

Main Methods:

  • Systematic review and meta-analysis of existing literature.
  • Graded recommendation development based on evidence quality.
  • Analysis of treatment outcomes and patient quality of life.

Main Results:

  • Conventional therapy is recommended as the first-line treatment for HypoPT.
  • Parathyroid hormone (PTH) replacement therapy is considered when conventional therapy is insufficient.
  • Close monitoring and therapy adjustment are crucial during pregnancy and lactation.

Conclusions:

  • Conventional therapy remains the initial approach for HypoPT.
  • Parathyroid hormone (PTH) replacement offers an alternative for refractory cases.
  • Emerging therapies show promise for improved efficacy and safety in HypoPT management.