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Antimicrobial peptides: A promising tool to combat multidrug resistance in SARS CoV2 era

Jasleen Saini1, Pritpal Kaur1, Naveen Malik2

  • 1Department of Biotechnology, Sri Guru Granth Sahib World University, Fatehgarh Sahib, Punjab, India.

Microbiological Research
|September 26, 2022
PubMed

Insights

Antimicrobial peptides (AMPs) show promise in treating COVID-19. These natural compounds are effective against SARS-CoV-2 and other respiratory viruses, offering a potential therapeutic strategy.

Area of Science:

  • Biochemistry
  • Virology
  • Pharmacology

Background:

  • COVID-19, caused by SARS-CoV-2, is a severe global health threat with no current treatments.
  • Antimicrobial drug resistance necessitates novel therapeutic approaches.
  • Naturally occurring compounds, like antimicrobial peptides (AMPs), offer potential solutions.

Purpose of the Study:

  • To explore the antiviral potential of antimicrobial peptides (AMPs) against SARS-CoV-2.
  • To review AMPs derived from natural sources effective against respiratory viruses.
  • To elucidate the mechanisms of action of antiviral peptides against SARS-CoV-2.

Main Methods:

  • Literature review of existing studies on AMPs and their antiviral properties.
  • Analysis of natural sources for effective antiviral peptides.
  • Examination of the mechanisms of action of AMPs against viral infections.

Main Results:

  • Antimicrobial peptides (AMPs) demonstrate significant potential as antiviral agents.
  • Several AMPs derived from natural sources show efficacy against SARS-CoV and other respiratory viruses.
  • AMPs exhibit diverse mechanisms of action against viral pathogens.

Conclusions:

  • Antimicrobial peptides (AMPs) represent a promising therapeutic strategy for COVID-19 treatment.
  • Further research into AMPs could lead to novel drugs to combat SARS-CoV-2.
  • The natural origin and broad-spectrum activity of AMPs make them attractive candidates for antiviral drug development.
Keywords:
Antimicrobial peptideAntimicrobial resistanceAntiviral peptidesSevere acute respiratory syndrome coronavirus

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