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Updated: Aug 27, 2025
Therapeutic Evaluation of Fecal Microbiota Transplantation in an Interleukin 10-Deficient Mouse Model
Published on: April 6, 2022
The effect of fecal microbiota transplantation on stroke outcomes: A systematic review
Amir Pasokh1, Mohammad Farzipour1, Javad Mahmoudi1
1Neurosciences Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Background And Purpose:
Fecal microbiota transplantation (FMT) is a novel microbiota-based therapeutic method that transfers stool from donor into a recipient and its application is under investigating for neurological disorders such as stroke. In this systematic review, we assessed the effect of FMT in progression and treatment of stroke and recovery of post-stroke complications.
Methods:
Preliminary studies were searched in MEDLINE via PubMed, Scopus, COCHRANE library and Google Scholar, databases up to February 2022. The search strategy was restricted to articles about FMT in stroke. The initial search yielded 4570 articles, of which 19 publications were included in our systematic review.
Results:
Based on outcomes transferring microbiome from healthy or ischemic donor to other ischemic recipient can affect brain infarct volume and survival rate, neurological and behavioral outcomes, and inflammatory pathways.
Conclusions:
Our systematic review on preclinical studies showed that manipulating gut microbiota via FMT can be a possible therapeutic approach for treatment of stroke and recovery of post-stroke complications.
Insights
Fecal microbiota transplantation (FMT) may offer a new therapeutic strategy for stroke. This approach, involving transferring gut microbes, shows potential in improving neurological outcomes and aiding recovery from stroke complications.
Area of Science:
- Microbiology
- Neurology
- Gastroenterology
Background:
- Fecal microbiota transplantation (FMT) is an emerging therapeutic strategy.
- Its potential application in neurological disorders, including stroke, is under investigation.
- This review assesses FMT's role in stroke progression, treatment, and post-stroke complication recovery.
Approach:
- A systematic review of preclinical studies on FMT and stroke was conducted.
- Searches were performed in major scientific databases (PubMed, Scopus, Cochrane, Google Scholar) up to February 2022.
- Nineteen relevant publications were included from an initial pool of 4570 articles.
Key Points:
- Transferring gut microbiota can influence key stroke indicators.
- FMT impacts brain infarct volume and survival rates.
- Neurological and behavioral outcomes, alongside inflammatory pathways, are affected by FMT.
Conclusions:
- Manipulating gut microbiota through FMT presents a potential therapeutic avenue for stroke.
- FMT may aid in the treatment of stroke.
- This approach shows promise for the recovery of post-stroke complications.
