Generation of¹⁸F-FDG PET standard scan images from short scans using cycle-consistent generative adversarial network

Objective.To improve positron emission tomography (PET) image quality, we aim to generate images of quality comparable to standard scan duration images using short scan duration (1/8 and 1/16 standard scan duration) inputs and assess the generated standard scan duration images quantitative and qualitatively. Also, the effect of training dataset properties (i.e. body mass index (BMI)) on the performance of the model(s) will be explored.Approach.Whole-body PET scans of 42 patients (41¹⁸F-FDG and one⁶⁸Ga-PSMA) scanned with standard radiotracer dosage were included in this study. One¹⁸F-FDG patient data was set aside and the remaining 40 patients were split into four subsets of 10 patients with different mean patient BMI. Multiple copies of a developed cycle-GAN network were trained on each subset to predict standard scan images using 1/8 and 1/16 short duration scans. Also, the models' performance was tested on a patient scanned with the⁶⁸Ga-PSMA radiotracer. Quantitative performance was tested using peak signal-to-noise ratio (PSNR), structural similarity index (SSIM), and normalized root mean squared error (NRMSE) metrics, and two nuclear medicine specialists analyzed images qualitatively.Main results.The developed cycle-GAN model improved the PSNR, SSIM, and NRMSE of the 1/8 and 1/16 short scan duration inputs both¹⁸F-FDG and⁶⁸Ga-PSMA radiotracers. Although, quantitatively PSNR, SSIM, and NRMSE of the 1/16 scan duration level were improved more than 1/8 counterparts, however, the later were qualitatively more appealing. SUV_meanand SUV_maxof the generated images were also indicative of the improvements. The cycle-GAN model was much more capable in terms of image quality improvements and speed than the NLM denoising method. All results proved statistically significant using the paired-sample T-Test statistical test (p-value < 0.05).Significance.Our suggested approach based on cycle-GAN could improve image quality of the 1/8 and 1/16 short scan-duration inputs through noise reduction both quantitively (PSNR, SSIM, NRMSE, SUVmean, and SUVmax) and qualitatively (contrast, noise, and diagnostic capability) to the level comparable to the standard scan-duration counterparts. The cycle-GAN model(s) had a similar performance on the⁶⁸Ga-PSMA to the¹⁸F-FDG images and could improve the images qualitatively and quantitatively but requires more extensive study. Overall, images predicted from 1/8 short scan-duration inputs had the upper hand compared with 1/16 short scan-duration inputs.