Autoantibodies to acrosomal antigens of spermatozoa in vasectomized mice

A total of 102 mice from seven different inbred strains were vasectomized or sham vasectomized. Sera from these animals were collected before vasectomy and at 7 and 10 months after the operation. Indirect immunofluorescence on sperm smears showed that 26 per cent of vasectomized mice had antibodies to arosomal antigens of spermatozoa. This response was restricted to three of seven strains. None of the sera obtained from animals before vasectomy or from sham-vasectomized control mice contained similar antibodies.