Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Allergic Reactions

Allergic Reactions

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs

Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...

Adrenergic Agonists: Therapeutic Uses

Adrenergic Agonists: Therapeutic Uses

Adrenergic agonists have diverse therapeutic uses across various medical conditions and emergencies.
Emergency and Intensive Care Unit (ICU) applications: Pressor agents increase blood pressure, heart rate, and contractility in shock and organ failure situations. Dopamine can induce vasodilation and stimulate adrenoceptors. Endogenous catecholamines are effective in treating cardiogenic shock. α2-agonists like clonidine can reverse anesthesia-induced hypertension.
Allergies and...

Allergic Drug Reactions

Allergic Drug Reactions

Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing...

Cross-reactivity

Cross-reactivity

Desensitization and Tachyphylaxis

Desensitization and Tachyphylaxis

Tachyphylaxis is described as a rapid decrease in response to a drug after repeated or continuous administration of the same drug dose. It is a phenomenon where the body becomes less responsive to a particular substance or intervention over time, requiring higher doses or stronger interventions to achieve the same effect. It results from adaptive changes in the body's receptors, signaling pathways, or physiological processes that occur in response to prolonged exposure to a stimulus.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Pharmacokinetics and pharmacodynamics of AQST-109 sublingual film in oral allergy syndrome: A phase 2 study.

Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology·2026

Same author

Stability of epinephrine nasal spray under room temperature, freeze-thaw, and extreme temperature conditions.

The journal of allergy and clinical immunology. In practice·2026

Same author

The 2025 WAO Guidelines for the classification, diagnosis, and treatment of hereditary angioedema, with consideration of worldwide disparities.

The World Allergy Organization journal·2026

Same author

Entering the era of somatic variant sequencing in immune dysregulation: comment on the article by Fu et al.

Arthritis & rheumatology (Hoboken, N.J.)·2026

Same author

Hypersensitivity to Excipients in Drugs: An EAACI Position Paper.

Allergy·2026

Same author

2025 Inborn errors of immunity practice parameter: Guidance from the Joint Task Force on Practice Parameters, the American Academy of Allergy, Asthma & Immunology (AAAAI), the American College of Allergy, Asthma and Immunology (ACAAI) and the Clinical Immunology Society (CIS).

Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology·2026

Search research articles

Related Experiment Video

Updated: Aug 27, 2025

Measuring Local Anaphylaxis in Mice

Measuring Local Anaphylaxis in Mice

Published on: October 14, 2014

Anaphylaxis: Advances in the Past 10 Years.

Catherine R Weiler¹, Rik Schrijvers², David B K Golden³

¹Division of Allergy, Mayo Clinic, Rochester, Minn.

The Journal of Allergy and Clinical Immunology. in Practice

|September 26, 2022

Summary

This summary is machine-generated.

Recent advances in anaphylaxis research include simplified diagnostics, better understanding of mast cell function, and new therapeutic targets. Epinephrine stability is confirmed, offering insights into severe allergic reactions.

Keywords:

Anaphylaxis Hereditary α-tryptasemia Injectable epinephrine Risk factors for anaphylaxis Vaccination-induced anaphylaxis α-Gal

More Related Videos

Antigenic Liposomes for Generation of Disease-specific Antibodies

Antigenic Liposomes for Generation of Disease-specific Antibodies

Published on: October 25, 2018

Humanized Mediator Release Assay as a Read-Out for Allergen Potency

Humanized Mediator Release Assay as a Read-Out for Allergen Potency

Published on: June 29, 2021

Related Experiment Videos

Last Updated: Aug 27, 2025

Measuring Local Anaphylaxis in Mice

Measuring Local Anaphylaxis in Mice

Published on: October 14, 2014

Antigenic Liposomes for Generation of Disease-specific Antibodies

Antigenic Liposomes for Generation of Disease-specific Antibodies

Published on: October 25, 2018

Humanized Mediator Release Assay as a Read-Out for Allergen Potency

Humanized Mediator Release Assay as a Read-Out for Allergen Potency

Published on: June 29, 2021

Area of Science:

Allergy-Immunology research
Mast cell biology
Clinical immunology

Background:

Anaphylaxis has emerged as a distinct subspecialty in Allergy-Immunology over the last decade.
Significant progress has been made in understanding and managing anaphylaxis at both research and clinical levels.

Approach:

Review of key clinical and research advancements in anaphylaxis over the past 10 years.
Focus on diagnostic criteria, mast cell regulation, novel causes, and therapeutic strategies.

Key Points:

Simplified diagnostic criteria and objective severity grading for anaphylaxis.
Enhanced understanding of mast cell regulation, disorders, and hereditary α-tryptasemia.
Identification of new causes (e.g., α-gal), pathways (e.g., MRGPRX2), and risk factors for severe anaphylaxis.
Confirmation of epinephrine autoinjector stability under various conditions, with heat sensitivity noted.
Emergence of novel preventive treatments targeting IgE receptor and intracellular signaling.

Conclusions:

The past decade has yielded substantial progress in the diagnosis, understanding, and treatment of anaphylaxis.
Ongoing research continues to refine management strategies and identify new therapeutic avenues for severe allergic reactions.