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Updated: Aug 27, 2025

Detection of Alternative Splicing During Epithelial-Mesenchymal Transition
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Underlying mechanisms of epithelial splicing regulatory proteins in cancer progression

Ying Liu1,2, Yiwen Li3, Chengcheng Du3

  • 1Institute for Translational Medicine, The Affiliated Hospital of Qingdao University, Qingdao Medical College, Qingdao University, Qingdao, 266021, China. liuying_hero@163.com.

Journal of Molecular Medicine (Berlin, Germany)
|September 27, 2022
PubMed

Insights

Epithelial splicing regulatory proteins (ESRPs) are vital for cell function and are implicated in cancer. Understanding ESRPs offers new avenues for cancer diagnostics and treatments.

Area of Science:

  • Oncology
  • Molecular Biology
  • RNA Biology

Background:

  • Cancer is a leading cause of global mortality, with complex pathogenesis.
  • Epithelial splicing regulatory proteins (ESRPs) regulate alternative splicing of messenger RNAs (mRNAs).
  • ESRP dysregulation is linked to cancer progression, but mechanisms are unclear.

Purpose of the Study:

  • To review the structure, function, and regulation of ESRPs.
  • To elucidate the role of ESRPs in cancer progression.
  • To highlight ESRPs as potential cancer biomarkers and therapeutic targets.

Main Methods:

  • Literature review of recent findings on ESRPs.
  • Analysis of ESRP structure, function, and regulatory mechanisms.
  • Examination of ESRP involvement in cancer pathogenesis.

Main Results:

  • ESRPs (ESRP1 and ESRP2) are RNA-binding proteins crucial for alternative splicing.
  • ESRP expression and activity are modulated by post-translational modifications and non-coding RNAs.
  • ESRP dysregulation is associated with various cancers, impacting progression.

Conclusions:

  • ESRPs play a significant role in cancer development and progression.
  • ESRPs hold promise as prognostic biomarkers for cancer patients.
  • Targeting ESRPs may lead to novel, individualized cancer therapeutics.
Keywords:
BiomarkerCSCEMTESRPsTherapeutic target

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