[Ultrastructural study of the liver in rabbits treated with diclofenac]

The existence of alterations of common indexes of hepatic function, and the case-reports of acute hepatitis after the use of diclofenac sodium are the rationale for this experimental study, in which 8 rabbits were given 15 mg/kg day of diclofenac, to check ultrastructural modifications with respect to a control group. The analysis showed the typical signs of primary and secondary microcholestasis, indicating the existence of liver distress. This finding, from a clinical standpoint, suggests caution in the administration of this drug, chiefly in the hepatopathic patients.