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Null Association Between Isolated Orofacial Clefts and Sleep Duration: A Cohort Study From the Japan Environment and

Yukihiro Sato1, Eiji Yoshioka1, Yasuaki Saijo1

  • 1Asahikawa Medical University, Asahikawa, Hokkaido, Japan.

The Cleft Palate-Craniofacial Journal : Official Publication of the American Cleft Palate-Craniofacial Association
|September 27, 2022
PubMed

Insights

Children with orofacial clefts show no difference in sleep duration compared to peers. This study found sufficient sleep in infants and toddlers with isolated cleft lip and palate, isolated cleft lip, or isolated cleft palate.

Area of Science:

  • Pediatrics
  • Genetics
  • Sleep Medicine

Background:

  • Orofacial clefts are associated with an increased risk of sleep-disordered breathing.
  • Limited research exists on the relationship between orofacial clefts and overall sleep duration in early childhood.

Purpose of the Study:

  • To investigate the association between isolated orofacial clefts and sleep duration in Japanese children.
  • To analyze sleep duration at multiple time points: 1 month, 6 months, 1 year, and 3 years of age.

Main Methods:

  • A large cohort study utilizing data from the Japan Environment and Children's Study (JECS).
  • Included 91,497 children, with specific subgroups for isolated cleft lip and palate, isolated cleft lip only, and isolated cleft palate only.
  • Sleep durations were self-reported by mothers at four distinct developmental stages.

Main Results:

  • No significant differences in sleep duration were found between children with isolated orofacial clefts and the control group at any measured time point.
  • Linear regression models indicated effect sizes less than 1 hour for all cleft types across all ages.
  • Children with isolated orofacial clefts consistently exhibited sufficient mean sleep duration.

Conclusions:

  • This study suggests a null association between isolated orofacial clefts and sleep duration in early childhood.
  • Infants and toddlers with orofacial clefts generally achieve adequate sleep duration, contrary to potential concerns regarding sleep disturbances.

Keywords:
cohort studyorofacial cleftssleep duration

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