Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Amyloid Fibrils03:03

Amyloid Fibrils

9.7K
Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining,...
9.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

An unusual case of a peritoneal dialysis catheter causing hydronephrosis: A case report.

Urology case reports·2024
Same author

Myocardial Characterization with Extracellular Volume Mapping with a First-Generation Photon-counting Detector CT with MRI Reference.

Radiology·2023
Same author

BCG orchitis.

Urology case reports·2019
Same author

A New Differential Diagnosis: Synthetic Cannabinoid-Associated Gross Hematuria.

Case reports in medicine·2019
Same author

Novel Role of Dehydrated Human Amnion/Chorion Membrane in Healing of Denuded Ureter in Robot-Assisted Excision of Endometriosis.

Case reports in obstetrics and gynecology·2019

Related Experiment Video

Updated: Aug 27, 2025

Isolation, Culture, and Characterization of Prostate Cancer-Associated Fibroblasts
09:43

Isolation, Culture, and Characterization of Prostate Cancer-Associated Fibroblasts

Published on: August 1, 2025

145

Isolated prostate amyloidosis; a case report.

Robert R Sibley1, Benjamin Ellison2, James J Siegert3

  • 1Department of Urology, Resident (PGY-4) at Franciscan Health Olympia Fields, USA.

Urology Case Reports
|September 27, 2022
PubMed
Summary

Prostate biopsy can reveal amyloidosis, raising concerns for systemic disease. This case highlights AL (lambda)-type amyloidosis diagnosed via MRI-TRUS fusion biopsy, alongside prostate cancer, without systemic involvement.

Keywords:
AmyloidosisProstate amyloidosisProstate cancer

More Related Videos

Purification and Aggregation of the Amyloid Precursor Protein Intracellular Domain
10:08

Purification and Aggregation of the Amyloid Precursor Protein Intracellular Domain

Published on: August 28, 2012

11.9K
MR Molecular Imaging of Prostate Cancer with a Small Molecular CLT1 Peptide Targeted Contrast Agent
06:54

MR Molecular Imaging of Prostate Cancer with a Small Molecular CLT1 Peptide Targeted Contrast Agent

Published on: September 3, 2013

11.3K

Related Experiment Videos

Last Updated: Aug 27, 2025

Isolation, Culture, and Characterization of Prostate Cancer-Associated Fibroblasts
09:43

Isolation, Culture, and Characterization of Prostate Cancer-Associated Fibroblasts

Published on: August 1, 2025

145
Purification and Aggregation of the Amyloid Precursor Protein Intracellular Domain
10:08

Purification and Aggregation of the Amyloid Precursor Protein Intracellular Domain

Published on: August 28, 2012

11.9K
MR Molecular Imaging of Prostate Cancer with a Small Molecular CLT1 Peptide Targeted Contrast Agent
06:54

MR Molecular Imaging of Prostate Cancer with a Small Molecular CLT1 Peptide Targeted Contrast Agent

Published on: September 3, 2013

11.3K

Area of Science:

  • Urology
  • Nephrology
  • Pathology

Background:

  • Amyloidosis diagnosis on prostate biopsy warrants investigation for systemic disease.
  • Prostate adenocarcinoma detection often requires MRI-TRUS fusion biopsy.
  • Elevated Prostate-Specific Antigen (PSA) is a common indicator for prostate evaluation.

Observation:

  • A 70-year-old male presented with an elevated PSA.
  • An MRI-TRUS fusion biopsy of the prostate was performed.
  • The biopsy revealed AL (lambda)-type amyloidosis and prostatic adenocarcinoma.

Findings:

  • Mass spectrometry confirmed AL (lambda)-type amyloidosis.
  • The patient was diagnosed with primary amyloidosis of the prostate.
  • No other sites of amyloid deposition were identified.

Implications:

  • This case underscores the importance of comprehensive evaluation for amyloidosis.
  • MRI-TRUS fusion biopsy is crucial for diagnosing prostate pathologies.
  • Primary prostatic amyloidosis is a rare entity that requires careful differentiation from systemic forms.