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IgG4 paratesticular fibrous pseudotumor: Case presentation and literature review
Layla Zeitouni1, Faiz Motiwala2, Neelakshi Goyal3
1Queen Elizabeth University Hospital, Glasgow, Scotland, UK.
Abstract:
PFP with IgG-4 immunostaining is a rare paratesticular tumour. Pre-operative ultrasound scan and MRI usually confirm the benign nature of the paratesticular mass avoiding the need for radical orchiectomy. The final diagnosis is based on histology of the removed paratesticular tumour. FDG PET scan plays an important role in ruling out systematic IgG4-related disease (IgG4-RD). We describe a case of multiple paratesticular fibrous pseudotumors with IgG4 immunostaining, not associated with systemic IgG4 related disease.
Insights
Pleomorphic fibroma (PFP) with IgG-4 immunostaining is a rare paratesticular tumor. This case highlights multiple PFP, not linked to systemic IgG4-related disease, emphasizing diagnostic approaches.
Area of Science:
- Urology
- Pathology
- Radiology
Background:
- Pleomorphic fibroma (PFP) with IgG-4 immunostaining is a rare paratesticular tumor.
- Pre-operative imaging like ultrasound and MRI typically confirms benign paratesticular masses, potentially avoiding radical orchiectomy.
Observation:
- This report details a unique case of multiple paratesticular fibrous pseudotumors exhibiting IgG-4 immunostaining.
- The observed tumors were not associated with systemic IgG4-related disease (IgG4-RD).
Findings:
- Histology of the excised paratesticular tumor is crucial for definitive diagnosis.
- FDG PET scans are valuable in excluding systemic IgG4-RD.
Implications:
- Accurate pre-operative diagnosis can prevent unnecessary radical orchiectomy for benign paratesticular masses.
- Understanding IgG-4 related paratesticular lesions aids in appropriate patient management and diagnostic workup.
