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Serum Caveolin-1 Level is Inversely Associated with Serum Vaspin, Visfatin, and HbA1c in Newly Diagnosed Men with

Hameed Hussein Ali1, Khalid Al-Rawi1, Yousif Khalaf2

  • 1Departemnt of Chemistry, College of Sciences, University of Anbar, Ramadi, Al-Anbar province Iraq.

Reports of Biochemistry & Molecular Biology
|September 27, 2022
PubMed
Abstract

Insights

Serum caveolin-1 (Cav-1) is significantly lower in men with new type 2 diabetes mellitus (T2DM). Low Cav-1 correlates with higher glucose and blood pressure, suggesting its potential as a T2DM diagnostic marker.

Area of Science:

  • Endocrinology
  • Metabolic Diseases
  • Biomarker Research

Background:

  • Serum caveolin-1 (Cav-1) levels are crucial indicators in various diseases.
  • Reduced serum Cav-1 is linked to increased insulin secretion and hyperinsulinemia.
  • Caveolin-1 plays a role in metabolic regulation and insulin sensitivity.

Purpose of the Study:

  • To investigate the relationship between serum Cav-1, vaspin, and visfatin in newly diagnosed men with type 2 diabetes mellitus (T2DM).
  • To assess the diagnostic potential of serum Cav-1 in T2DM.
  • To explore correlations between these markers and clinical parameters of T2DM.

Main Methods:

  • Enzyme-linked immunosorbent assay (ELISA) was used to measure serum Cav-1, vaspin, and visfatin levels.
  • Study included 82 newly diagnosed men with T2DM and 82 age- and BMI-matched non-diabetic controls.
  • Fasting serum glucose (FSG), HbA1c, blood pressure, and anthropometric measurements were recorded.

Main Results:

  • Men with newly diagnosed T2DM showed significantly lower serum Cav-1 levels compared to controls (2.334±0.7627 vs. 4.321±1.143 ng/mL, p<0.0001).
  • T2DM patients had significantly higher serum vaspin and visfatin levels (142.4±60.53 and 2.99±1.091 ng/mL, respectively) than controls.
  • Inverse correlations were observed between Cav-1 and vaspin, visfatin, HbA1c, FSG, and hypertension.

Conclusions:

  • Serum Cav-1 is significantly reduced in men with newly diagnosed T2DM.
  • Serum Cav-1 demonstrates an inverse relationship with key T2DM indicators like HbA1c, FSG, and hypertension.
  • Serum Cav-1 may serve as a valuable diagnostic marker for predicting T2DM in high-risk individuals and families.
Keywords:
Caveolin-1HbA1cInsulin resistanceT2DMVaspinVisfatin

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