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Updated: Aug 27, 2025

Modeling Primary Bone Tumors and Bone Metastasis with Solid Tumor Graft Implantation into Bone
Published on: September 9, 2020
Skull metastases from extramammary Paget's disease emerging 8 years after initial treatment with no local
Taku Inada1, Takuya Nakakuki1, Norio Nakajima1
1Departments of1Neurosurgery.
Background:
The foci of distant metastasis from extramammary Paget's disease (EMPD) are the lung, liver, truncal bones, vertebrae, and brain. However, skull metastases have not been reported.
Observations:
The authors treated a patient with calvarial and skull base metastases from EMPD who had undergone wide local resection of EMPD 8 years before, and they report his clinical course.
Lessons:
Because EMPD with distant metastasis is fatal, it should be recognized that EMPD can metastasize to the skull even when it seemed to be in remission for several years.

