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IgD in infant saliva.

M Gleeson, A W Cripps, R L Clancy

    Scandinavian Journal of Immunology
    |July 1, 1987
    PubMed
    Summary
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    Salivary immunoglobulin D (IgD) was higher in newborns and rarely detected after six months. This suggests a physiological deficiency in immunoglobulin A (IgA) synthesis at mucosal sites.

    Area of Science:

    • Immunology
    • Pediatrics
    • Mucosal Immunity

    Background:

    • Immunoglobulin D (IgD) plays a role in mucosal immunity, but its ontogeny in infants is not well understood.
    • Salivary immunoglobulins are crucial for protecting mucosal surfaces.
    • Previous research suggests a complex interplay between different immunoglobulin classes at mucosal sites.

    Purpose of the Study:

    • To investigate the developmental patterns (ontogeny) of IgD in the saliva of healthy infants.
    • To explore the relationship between salivary IgD and other immunoglobulins (IgA, IgG) and albumin.
    • To assess the potential link between salivary IgD levels and IgA synthesis at mucosal surfaces.

    Main Methods:

    • Prospective study of 27 healthy, full-term infants.
    • Measurement of IgD concentrations and detection rates in saliva samples over time.

    Related Experiment Videos

  • Analysis of correlations between IgD and IgA, IgG, and albumin levels.

    • Main Results:

    • Salivary IgD concentrations and detection rates were highest near birth.
    • After six months of age, IgD was infrequently detected in saliva.
    • An inverse association was observed between salivary IgD and IgA detection, while no correlation was found with IgG or albumin.

    Conclusions:

    • Salivary IgD levels in infants decrease significantly after the neonatal period.
    • The inverse relationship between salivary IgD and IgA supports the hypothesis of a 'physiological' deficiency in IgA synthesis at mucosal sites.
    • These findings contribute to understanding the ontogeny of mucosal immunity and the role of IgD in early life.