Long-term twice-daily oral acyclovir therapy suppresses frequently recurrent genital herpes

The efficacy of oral acyclovir in a twice-daily treatment regime was demonstrated in an open long-term study in 8 patients with frequently relapsing genital herpes type II infections. The treatment was well tolerated and no side effects were noted during the medication period of 6-21 months. No signs of decreased sensitivity for acyclovir appeared.