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Updated: Aug 27, 2025
Author Spotlight: Noninvasive Cerebral Blood Flow Determination in Human Functional Brain Region for Diagnosis of Neurological Disorders
Published on: May 31, 2024
Effects of different regional cerebral blood flow on white matter hyperintensity in CADASIL patients
Runrun Wang1, Jiewen Zhang1, Junkui Shang1
1Department of Neurology, Henan Provincial People's Hospital, Zhengzhou University People's Hospital, Henan University People's Hospital, Zhengzhou, Henan 450003, China.
Insights
Reduced cerebral blood flow (CBF) in white matter hyperintensity (WMH) regions is linked to WMH severity in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). This finding highlights CBF
Area of Science:
- Neurology
- Neuroimaging
- Vascular Biology
Background:
- Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is an inherited small vessel disease.
- Decreased cerebral blood flow (CBF) is hypothesized to contribute to white matter hyperintensity (WMH) severity in CADASIL.
Purpose of the Study:
- To investigate the relationship between regional CBF and WMH volume in CADASIL patients.
- To determine if reduced CBF influences WMH severity.
Main Methods:
- Studied six CADASIL patients with NOTCH3 mutations and twelve healthy controls.
- Collected clinical and imaging data, analyzing CBF in WMH, normal-appearing white matter (NAWM), gray matter (GM), and global brain regions.
- Correlated regional CBF with WMH volume, applying correction tests.
Main Results:
- CADASIL patients showed significantly decreased CBF in all four brain regions compared to controls.
- Lower CBF in all regions correlated with higher WMH volume.
- After correction, only CBF in the WMH region, not NAWM, GM, or global regions, was significantly associated with WMH volume.
Conclusions:
- CBF within white matter hyperintensity regions is a key factor influencing WMH severity in CADASIL.
- This suggests targeted interventions to improve CBF in affected white matter may be beneficial.
Abstract:
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is an early-onset inherited small vessel disease. Decreased cerebral blood flow (CBF) may contribute to white matter hyperintensity (WMH) severity in CADASIL, but more evidence is needed to support this hypothesis. This study comprised six patients with CADASIL who harbored mutations in the coding sequence of NOTCH3 and twelve age-matched neurologically healthy controls. We collected clinical and imaging data from patients with CADASIL and divided the brain into four regions: WMH, normal-appearing white matter (NAWM), gray matter (GM), and global brain. We analyzed the relationship between CBF of each region and the WMH volume. Compared with the control group, CBF was significantly decreased in all four regions in the CADASIL group. Lower CBF in these regions was correlated with higher WMH volume in CADASIL. CBF in the NAWM, GM and global regions was positively correlated with that in WMH region. However, after correction tests, only CBF in the WMH region but not in NAWM, GM and global regions was associated with WMH volume. Our findings suggest that CBF in the WMH region is an influencing factor of the WMH severity in CADASIL.
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