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Related Concept Videos

Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

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Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
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Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

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Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
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Myocarditis II: Clinical Features and Diagnostic Tests01:27

Myocarditis II: Clinical Features and Diagnostic Tests

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Myocarditis is an inflammation of the heart muscle. The symptoms vary widely, encompassing asymptomatic presentations to severe, acute manifestations.Clinical PresentationAsymptomatic cases: In some instances, myocarditis may be asymptomatic, with the infection resolving without intervention. These cases often go undetected unless discovered incidentally through diagnostic imaging or tests conducted for other reasons.General Early Symptoms: Early symptoms of myocarditis are non-specific and can...
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Nephrotic Syndrome I : Introduction01:24

Nephrotic Syndrome I : Introduction

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Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of...
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Related Experiment Video

Updated: Aug 27, 2025

Separation of Immune Cell Subpopulations in Peripheral Blood Samples from Children with Infectious Mononucleosis
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Multisystem inflammatory syndrome in children.

Kelly R Porta1, Christine Zammit

  • 1Kelly R. Porta is an instructor in medicine in the PA program at Weill Cornell Graduate School of Medical Sciences in New York, N.Y., and practices in the pediatric ICU at Jacobi Medical Center in the Bronx, N.Y. Christine Zammit is an assistant professor and academic coordinator in the PA program at Hofstra University in Hempstead, N.Y., and practices in the pediatric ICUs at Hassenfeld Children's Hospital in New York, N.Y., and Jacobi Medical Center. The authors have disclosed no potential conflicts of interest, financial or otherwise.

JAAPA : Official Journal of the American Academy of Physician Assistants
|September 27, 2022
PubMed
Summary
This summary is machine-generated.

Multisystem inflammatory syndrome in children (MIS-C) is a serious condition linked to COVID-19. This report details MIS-C's overview, definition, epidemiology, pathogenesis, clinical findings, and management.

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Area of Science:

  • Pediatric infectious diseases
  • Critical care medicine
  • Public health

Background:

  • The COVID-19 pandemic has been associated with the emergence of Multisystem Inflammatory Syndrome in Children (MIS-C).
  • Understanding MIS-C is crucial for effective clinical response and public health strategies.
  • This report provides a comprehensive overview of MIS-C.

Observation:

  • MIS-C presents as a severe, systemic inflammatory condition in pediatric populations.
  • Clinical manifestations can be diverse, affecting multiple organ systems.
  • Early recognition and diagnosis are vital for patient outcomes.

Findings:

  • The report covers the established case definition, epidemiological trends, and proposed pathogenetic mechanisms of MIS-C.
  • Detailed clinical findings across various affected systems are presented.
  • Current management strategies, including supportive care and immunomodulatory therapies, are discussed.

Implications:

  • This overview aids clinicians in diagnosing and managing MIS-C patients.
  • Understanding MIS-C pathogenesis may lead to targeted therapeutic interventions.
  • Public health awareness and preparedness for MIS-C are essential during viral pandemics.