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Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment
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HER2 and HER3 as Therapeutic Targets in Head and Neck Cancer

Robert Saddawi-Konefka, Shiruyeh Schokrpur, Asona J Lui

    Cancer Journal (Sudbury, Mass.)
    |September 27, 2022
    PubMed

    Insights

    Aberrant ErbB signaling pathways, particularly HER2 and HER3, drive head and neck cancers. Targeting these pathways with small molecules or antibodies shows promise for precision therapies.

    Area of Science:

    • Oncology
    • Molecular Biology
    • Cancer Signaling

    Background:

    • Aberrations in ErbB signaling pathways are key drivers of oncogenesis.
    • Targeting these pathways offers promise for treating human cancers.
    • EGFR (HER1) targeted therapies are approved for head and neck cancer.

    Purpose of the Study:

    • To review HER2 and HER3 signaling pathways in head and neck cancer.
    • To highlight clinical efforts targeting HER2 and HER3.
    • To discuss treatment strategies for head and neck malignancies.

    Main Methods:

    • Review of scientific literature on ErbB signaling.
    • Analysis of clinical trials and therapeutic strategies.
    • Focus on small molecule inhibitors and blocking antibodies.

    Main Results:

    • HER2 and HER3 signaling pathways are highly dysregulated in head and neck cancer.
    • Targeting HER2 and HER3 is a promising therapeutic strategy.
    • Combination therapies including targeted agents and immunotherapies are being explored.

    Conclusions:

    • Targeting HER2 and HER3 represents a significant advancement in head and neck cancer treatment.
    • Precision therapies offer new hope for patients with head and neck squamous cell carcinomas and salivary gland carcinomas.
    • Further research into multimodal precision targeted and immunotherapies is warranted.

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