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Development of ocular inserts for cattle.

R T Greer, J P Ryoo

    Scanning Microscopy
    |June 1, 1987
    PubMed
    Summary
    This summary is machine-generated.

    New ring-shaped ocular inserts deliver tylosin tartrate for five days to treat cattle pinkeye. These polyvinyl chloride inserts, coated with a copolymer, show promising results for sustained antibiotic release in veterinary medicine.

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    Area of Science:

    • Veterinary Ophthalmology
    • Drug Delivery Systems
    • Materials Science

    Background:

    • Bovine infectious keratoconjunctivitis (pinkeye) is a common cattle disease causing significant economic losses.
    • Current treatments for pinkeye can be labor-intensive and may not provide sustained therapeutic drug levels.
    • Ocular inserts offer a potential method for prolonged and targeted drug delivery to the eye.

    Purpose of the Study:

    • To develop and characterize novel ring-shaped ocular inserts for sustained delivery of tylosin tartrate.
    • To evaluate the fabrication process and surface properties of the inserts using Scanning Electron Microscopy (SEM).
    • To assess the in vitro release kinetics of tylosin tartrate from the inserts under simulated tear conditions.

    Main Methods:

    • Polyvinyl chloride (PVC) rings were dip-coated with a copolymer containing tylosin tartrate.

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  • Scanning Electron Microscopy (SEM) was used for surface flaw evaluation and fabrication quality control.
  • In vitro release rates were quantified using thin-layer chromatography at simulated tear rates.

    • Main Results:

    • SEM characterization identified and helped mitigate surface flaws, ensuring improved fabrication quality.
    • The inserts demonstrated sustained release of tylosin tartrate for up to nine days.
    • Release rates exceeded a few micrograms per hour even at high simulated tear rates (2 mL/hour).

    Conclusions:

    • Ring-shaped ocular inserts are a viable platform for sustained tylosin tartrate delivery in cattle.
    • The fabrication process, optimized using SEM, leads to improved insert quality and functionality.
    • These inserts represent a promising approach for effective and convenient treatment of pinkeye in cattle.