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Updated: Aug 27, 2025

Quantitative Magnetic Resonance Imaging of Skeletal Muscle Disease
Published on: December 18, 2016
Synthetic Contrasts in Musculoskeletal MRI: A Review
Tom Hilbert, Patrick Omoumi1, Marcus Raudner
1Department of Radiology, Lausanne University Hospital (CHUV), Lausanne, Switzerland.
Abstract:
This review summarizes the existing techniques and methods used to generate synthetic contrasts from magnetic resonance imaging data focusing on musculoskeletal magnetic resonance imaging. To that end, the different approaches were categorized into 3 different methodological groups: mathematical image transformation, physics-based, and data-driven approaches. Each group is characterized, followed by examples and a brief overview of their clinical validation, if present. Finally, we will discuss the advantages, disadvantages, and caveats of synthetic contrasts, focusing on the preservation of image information, validation, and aspects of the clinical workflow.
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