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Lymphomas Affecting the Sublingual Glands: A Clinicopathological Study.

Gabriela Ribeiro de Araújo1, Ana Luísa Morais-Perdigão1, Cinthia Verónica Bardález Lopez de Cáceres2

  • 1Department of Oral Surgery and Pathology, School of Dentistry, Universidade Federal de Minas Gerais, Av. Antônio Carlos, Belo Horizonte, 6627, Brazil.

Head and Neck Pathology
|September 27, 2022
PubMed
Summary
This summary is machine-generated.

Lymphomas of the sublingual gland are rare, often low-grade mature B-cell neoplasms. These sublingual gland lymphomas can mimic common salivary gland tumors, necessitating careful diagnosis.

Keywords:
Floor of the mouthFollicular lymphomaLymphomaMALT lymphomaOral cavitySublingual salivary gland

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Area of Science:

  • Pathology
  • Oncology
  • Head and Neck Surgery

Background:

  • Lymphomas involving the sublingual glands are exceptionally rare.
  • Limited case reports exist, highlighting a knowledge gap.

Purpose of the Study:

  • To characterize the clinicopathological features of sublingual gland lymphomas.
  • To contribute to the understanding of these rare malignancies.

Main Methods:

  • Retrospective analysis of seven sublingual gland lymphoma cases from four pathology services.
  • Review of histopathology and clinical data.

Main Results:

  • Seven cases identified: 2 follicular lymphomas, 2 diffuse large B-cell lymphomas (DLBCL NOS), 2 MALT lymphomas, and 1 mantle cell lymphoma (MCL).
  • Tumor cells infiltrated glandular parenchyma; some cases showed superficial permeation.
  • Most presented as asymptomatic nodules; outcomes varied, with two deaths (DLBCL NOS, MCL) and five survivors.

Conclusions:

  • Sublingual gland lymphomas are typically mature B-cell neoplasms, often low-grade.
  • They can present clinically similar to common salivary gland tumors.
  • Accurate diagnosis is crucial for appropriate management.